Scrotal Hemorrhage after TesticularSperm Aspiration may be Associated withPhosphodiesterase-5 Inhibitor Administration

Scrotal hemorrhage after testicular sperm aspiration (TESA) is uncommon in clinical operation. Unfortunately, two masturbation difficulty males experienced scrotal hemorrhage after TESA associated with phosphodiesterase-5 inhibitor (PDE5i) administration. Till now, reports about such cases are scarce. In this retrospective study, 504 men with TESA operation in Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University were collected. The testis volume, coagulation function were measured. Sonographic examination with Doppler imaging was performed when scrotal hemorrhage unfortunately appeared. The incidence of hemorrhage was 0.0% in the control group and the drug group was 2.6%. The incidence of hemorrhage between two groups was different significantly (χ2=11.308, P=0.001). Given the potential risk of scrotal hemorrhage after the ingestion of PDE5i, it should be cautious to prescribe this medicine when the patient is likely to perform TESA.